The IEEE 14th International Symposium on Embedded Multicore/Many-core Systems-on-Chip (MCSoC-2021) aims to provide the world’s premier forum of leading researchers in the Embedded Multicore/Many-core SoCs software, tools, and applications design areas for academia and industries. From the 2018 edition, the MCSoC symposium targets new emerging topics related to multicore neuro-inspired computing architectures and systems. Prospective authors are invited to submit their contributions. Submission of a contribution implies that at least one of the authors will have a full registration to the symposium upon acceptance of his/her contribution. Submission can include, technical and experimental, theoretical, conceptual, or a survey.